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Published 19:45 23 Sept 2022 BST
Updated 10:41 24 Sept 2022 BST
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He said: "Look, clearly, it’s not an ideal situation. You want your best players playing regularly so that they’re physically in a good place and mentally in a good place.
"But he is an important player for us. I think it’s important to back our best players.
"He was in the team of the tournament [Euro 2020], he's a big player for us and very important."
Maguire starts at the back alongside Eric Dier, who makes his first international appearance since featuring in a 4-0 win against Iceland in November, 2020.
Ivan Toney meanwhile will have to wait for a debut after failing to be included in the 23-man squad for the fixture at the San Siro.
Defeat for England will see them relegated from their Nations League group in what id their penultimate game before they officially begin their World Cup campaign in Qatar.
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