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Published 09:24 16 May 2016 BST
Updated 09:39 16 May 2016 BST
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One really touching scene was Louis' friendship with Natalie, an upbeat and carefree Liverpudlian women who claims things have "only gotten better" since her accident.
The resultant conversations and the unravelling of Natalie's story are some of the most engaging and heart-melting scenes to feature on a BBC doc to date.
Later in the show, Louis discovers that Earl's brain injury has lead to him developing unusual habits like cleaning his teeth multiple times a day and only buying designer clothing.
Particularly touching was Louis relationship with Earl's mum, who during one candid and teary-eyed chat in the kitchen says: “He’s a different person, but he’s still my son."
https://www.youtube.com/watch?v=dfSz2TkEKEs
As with most of Louis' work, the Twitter reaction following the show has been a mixture of delight and dismay. Not a single negative comment has been hurled at the presenter though, who seems to have firmly cemented his reputation as a national treasure.
Give this man a knighthood already!
https://twitter.com/hayleyleese_/status/731986843667972097
https://twitter.com/hayleyleese_/status/731979398820339712
https://twitter.com/RevRichardColes/status/731942489523884032
https://twitter.com/LeePKelly/status/731942317339361281
https://twitter.com/ptr_yeung/status/731943070023946241
https://twitter.com/joeswarbrick7/status/731947819955855360
https://twitter.com/CarolineKnight/status/731959292568424449
https://twitter.com/sudeeni/status/731959497674084353
https://twitter.com/CharlesWellsON/status/731944217413619713
https://twitter.com/adrian_yan/status/731939809594363904
https://twitter.com/JohnPudney/status/731943032367484928
Don't worry if you missed A Different Brain - you can still catch it on the BBC's iPlayer.
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