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Published 11:11 17 Nov 2015 GMT
Updated 12:03 17 Nov 2015 GMT
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It is believed the actor will be talking about the speculation that he is HIV positive.
Sheen - who has a daughter, Cassandra, 30, with ex-girlfriend Paula Profit, daughters Sam, 11, and Lola, 10, with ex-wife Denise Richards, and twins Bob and Max, six, with former spouse Brooke Mueller - will sit down for an interview with 'Today' host Matt Lauer.
In light of the rumours, his ex-girlfriend Bree Olson took to Twitter to Monday to reveal that she was getting tested for the disease.
https://twitter.com/BreeOlson/status/666350407308963840?ref_src=twsrc%5Etfw
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