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Published 15:05 15 Jan 2017 GMT
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A draw doesn't exactly suit either side.
Liverpool could move into second with a win, and leave themselves five points away from Chelsea at the top of the table. They could also put a significant dent in United's push for a top four place.
Mourinho's side will be just two points behind Liverpool in fourth if they win.
A game of football might just occur this time.
The history of this fixture points to a home win. Liverpool have lost 11 of their last 14 league matches at Old Trafford, while United are on their best run for eight years.
Mourinho's team won their last nine games in all competitions. Liverpool have also only kept three sheets away from home this season.
Here's the United team, which has no place for Juan Mata.
https://twitter.com/ManUtd/status/820646748192382977
And here's the Liverpool team, shorn of Joel Matip because of a failure to get clearance from FIFA.
https://twitter.com/LFC/status/820646524472487936
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