Manchester United will face Watford without both Wayne Rooney and Anthony Martial due to illness and injury respectively.
Louis van Gaal made the admission to MUTV on the eve of the game, adding that Michael Carrick, Marouane Fellaini and Antonio Valencia will also miss the game.
Valencia will be out until the new year with a foot injury that requires an operation, though the attacking duo are in contention to return against PSV in midweek.
https://twitter.com/ManUtd/status/667639965556342785
The striker crisis could mean James Wilson gets his first league start of the campaign, though it has been suggested that Memphis Depay could be used as a false nine.
United can temporarily go top of the Premier League with a win in Saturday's early kick-off, though their opponents have conceded just four goals in their six home matches so far.
