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Published 11:25 4 Apr 2015 BST
Updated 15:32 4 Apr 2015 BST
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But what is the best case scenario for the Old Trafford club? A home win, an away victory, or a stalemate? We run the rule over the possible permutations...
Thanks to a pivotal result at Anfield, there is currently a five-point gap between Manchester United and Liverpool. This could easily disappear in coming weeks but it gives United some vital breathing space. Manchester City and Arsenal also remain well within their sights.
Assuming Arsenal prevail at home and United beat Aston Villa later in the day, this opens up an eight-point gap between the Mancs and the Scousers.
With seven games remaining that would be a huge margin to haul back. It would also see both Arsenal and United leapfrog Manchester City before the Blues' tricky away fixture at Selhurst Park on Monday.
Were Liverpool to take maximum points (and United do the same), it would propel the Red Devils to second in the league, until Monday evening at least.
It would improve their chances of finishing in the top three, thus avoiding qualification for the Champions League group stages, but also make top four less certain with Liverpool still hovering five points behind.

A draw could be seen as the best of both worlds, but also a less than ideal result for either looking ambitiously through the windscreen, or pensively at the rear-view mirror.
It is certainly a conundrum for Louis Van Gaal's Red and White Army, but one thing is for certain - any outcome will be an opportunity wasted if United don't capitalise at home later in the day.Quiz: Name every third place play-off winner in World Cup history
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