Arsenal will fancy their chances at Southampton, who will take on Arsene Wenger's side without talisman Graziano Pelle.
The Italian misses out through injury, while defender Cedric is also sidelined. Shane Long and Cuco Martina start in place of the duo.
Arsenal, meanwhile, are unchanged from the team that beat Manchester City at the Emirates Stadium.
Three points at St Mary's would see the visitors move to the top of the Premier League table.
https://twitter.com/SouthamptonFC/status/680821641614614528
https://twitter.com/Arsenal/status/680821693598842881
