The press conference comes amid ongoing problems with Covid tests and booster jab bookings
Boris Johnson is to lead a Downing Street news conference at 5pm on Wednesday.
The prime minister will be joined by England's chief medical officer Professor Chris Whitty and Dr Nikki Kanani, medical director of primary care for NHS England.
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The briefing is expected to focus on the booster jabs rollout and comes amid fears that up to 1 million Brits will be isolating on Christmas as Omicron sweeps across the nation.
Official estimates suggest that four times more people are likely to be isolating on Christmas Day than last year.
The press conference also comes amid ongoing problems around the availability of Covid tests and the government website being besieged by demand for booster jabs leading to long delays.
Government minister Alex Burghart has told the Commons that more than 50 per cent of cases of Covid in London are now Omicron.
This number was at around a third on Sunday, with scientist warning the variant is spreading rapidly.
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