Having briefly topped the Premier League over the weekend, many might have expected Arsenal's meeting with Sheffield Wednesday to be a formality.
However, the first half couldn't have gone any worse for Arsene Wenger, after watching his side go two goals down and lose two key players to injury.
First up, Alex Oxlade-Chamberlain left the field with a problem after just five minutes.
https://twitter.com/StanCollymore/status/659094729859182592
But soon after, his replacement, Theo Walcott, was also forced off.
https://twitter.com/GaryLineker/status/659098391499161600
Losing Walcott, who has been in fantastic form of late, was clearly a blow - and some were quick to point the finger at Arsene Wenger.
https://twitter.com/afcstuff/status/659099024826478592
But not everyone agreed it was the manager's fault.
https://twitter.com/CostAFC_/status/659099871924895744
As Sheffield Wednesday took a 2-0 lead, the wider impact of the two injuries on Arsenal's title aspirations was not lost on those on Twitter.
https://twitter.com/JasonLeMiere/status/659098743904579584
https://twitter.com/Torres_K10/status/659103978093957120
